The only time that you could have a problem switching to synth from dino is if the engine is old and has a lot of sludge and crap in it. The synth flows better and I have heard of seals leaking some once the gunk has been cleaned out of them. If you are dealing with a relatively new engine and it has been well maintained you should have no problems with the switch. I used synth in a mustang I bought once that was kind of a high miler and while it did not leak, it did use a bit more oil (not a smoker, just normal consumption) than when I switched back to dino.
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 '03 Inferno Red GT, 5 speed, STAGE 1, Mopar BOV, Plastic Intake, Modified Upper and Lower Airbox, Custom Airbox-to-turbo pipe, Borla dual exhaust, Maddog Short Shifter, Drilled/Slotter Rotors, Ceramic Pads, chrome wheels, chrome door spears, AMP chrome fuel door, PT Cruiser 3rd light diffuser, H&R Springs, Rear Sway Bar added, MGW chrome door lock pulls, Blane's hood struts, Custom license plate mount, some interior dress up stuff...more to come
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